![]() Study-specific associations were estimated using generalized least-squares regression and the pooled association was estimated by combining the study-specific coefficients using restricted maximum likelihood. A 2-stage random-effects dose-response meta-analysis was used to synthesize data. Study Selection We included prospective cohort studies reporting physical activity at 3 or more exposure levels and risk estimates for depression with 3000 or more adults and 3 years or longer of follow-up.ĭata Extraction and Synthesis Data extraction was completed independently by 2 extractors and cross-checked for errors. The date of the search was November 12, 2020. Objective To systematically review and meta-analyze the dose-response association between physical activity and incident depression from published prospective studies of adults.ĭata Sources PubMed, SCOPUS, Web of Science, PsycINFO, and the reference lists of systematic reviews retrieved by a systematic search up to December 11, 2020, with no language limits. ![]() Importance Depression is the leading cause of mental health–related disease burden and may be reduced by physical activity, but the dose-response relationship between activity and depression is uncertain. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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